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Electronic nicotine delivery systems exhibit reduced ...
Thus, the number of puffs for 1R6F WS was set at five (mean nicotine concentration 8.55 ± 0.78 μg/mL), at 25 puffs for Vype eStick (8.8 ± 2.4 μg/mL), at 10 puffs for Vype ePen 3 (8.47 ± 1.54 ...
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Jessica WILSON Senior Product Specialist PhD
Jessica M. Wilson. Christopher K Thompson. Laura Miller McPherson. Charles J Heckman. The intrinsic excitability of spinal motoneurons is mediated in part …
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Cisco Webex Calling for SP Call Detail Record (CDR
Webex Calling for SP - Call Detail Record Download Service ©2020 Cisco Inc. Proprietary. Do not duplicate or distribute. Page 4 1. Introduction This document describes the mediated Call Detail Record (CDR) service that allows access to detailed call
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National Fire Academy online courses
National Fire Academy online courses. Online learning is a terrific option if you want to take National Fire Academy (NFA) classes. Our online self-study and mediated courses are free to fire and emergency services personnel, and international stude
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Gregg Bertram – Mediation and Arbitration for Global
Gregg Bertram is the founder of Pacific ADR and is one of the Pacific Northwest’s most experienced and respected mediator/arbitrators. In the past twenty five years Gregg has successfully mediated several thousand civil cases of virtually every dimension. Gregg is a former JAMS shareholder and was previously designated “Master Mediator” by his first ADR service provider, Washington
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Contact Lens Problems View issues and treatments
Contact Lens Associated Immune Keratitis or CL-induced red eye (CLARE) – is a condition in which the body becomes sensitised to endotoxins from bacteria resulting in an immune mediated inflammation of the cornea which can disturb the corneal lining
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Structure and Shape of Surface-Mediated Assembly of ...
Densification of the core on adding P123 is noted from the decrease in the core radius from 15.9 to 14.6 Å. The presence of a quartz substrate causes the micelles to elongate, which is noted by the emergence of a power-law slope in the low q region (<0.02 Å –1 ).
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Mediated Communication - an overview | ScienceDirect Topics
For example, speaking or texting via mobile phone offers the highest media mobility (Dimmick et al., 2011). Computer-mediated communication such as email, video chat, and IM provide some mobility, especially with the growing number of tablet, laptop, and smartphone users but their use is less facile than that of mobile phones.
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Energy stress-mediated AMPK activation inhibits ferroptosis
Energy stress inhibits ferroptotic cell death. a, Representative images showing the induction of cell death in immortalized MEFs treated with 2 μM erastin cultured in 25 mM or 0 mM glucose for 16 h.Scale bars, 100 μm. b-d, Cell death measurement in MEFs cultured in 25 mM or 0 mM glucose and treated with 2 μM erastin for 16 h (b), cultured in cysteine-free media for 8 h (c), or …
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Wisdom — Robert J. Sternberg
Balance Theory of Wisdom. The balance theory defines wisdom as the use of one’s intelligence, creativity, commone sense, and knowledge and as mediated by positive ethical values toward the achievement of a common good through a balance among (a) intrapersonal, (b) interpersonal, and (c) extrapersonal interests, over the (a) short and (b) long terms to achieve a balance among …
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Social Networking Sites, Depression, and Anxiety: A ...
A number of studies have made a more nuanced consideration of SNS use frequency by looking at the different functions of use of SNSs [54,56,69,74-76,78]. Table 1 presents how these broad functions have been defined in the literature and presents some example behaviors. It also provides the Cronbach alphas that have been reported for the ...
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Journal of Computer-Mediated ... - Wiley Online Library
Click on the title to browse this journal
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Partial recovery of visual function in a blind patient ...
E.B.-S. is a consultant for GenSight Biologics. D.D. was a consultant for GenSight Biologics, is a cofounder and acting Chief Strategy Officer of Gamut Tx. D.D. is an inventor on a patent of adeno ...
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Visible-Light-Mediated Cross Dehydrogenative Coupling of ...
Thioesters play a crucial role in biological systems and serve as important building blocks for organic synthesis. Herein, Eosin Y and TBHP mediated photochemical cross dehydrogenative coupling (PCDC) between feedstock aldehydes and thiols has been described at room temperature to synthesize thioesters. This thioesterification protocol proceeds smoothly …
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Abundance, Betweenness Centrality, Hydrophobicity, and ...
Adaptive cellular and humoral immune responses to infectious agents require previous recognition of pathogenic peptides bound to human leukocyte antigen (HLA) class II molecules exposed on the surface of the professional antigen-presenting cells. Knowledge of how these peptide ligands are generated is essential to understand the basis for CD4+ T-cell-mediated …
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Diagnosis and significance of antibody titers in anti-NMDA ...
Introduction. Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an immune-mediated disorder that associates with IgG antibodies against the GluN1 subunit of the NMDAR. 1 The antibody reactivity depends on the conformation of GluN1 expressed alone or in combination with GluN2 (GluN1/N2) in HEK293 cells (cell-based assay) 2 and it is always detectable with …
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Animal Models for Alopecia Areata: What and Where?
Introduction. Alopecia areata (AA) is a cell mediated autoimmune disease that targets anagen stage hair follicles in many mammalian species (Tables 1, ,2) 2) (McElwee and Hoffmann, 2002; Sundberg et al., 1995) and possibly even feathers in chickens (Smyth and McNeil, 1999).In humans, this disease has been subdivided clinically into alopecia areata (patchy hair loss), …
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Ritual Communication: From Everyday Conversation To ...
High school students have been getting help with their essays. College students - with term papers. And Ritual Communication: From Everyday Conversation To Mediated Ceremony|Eric W university graduates - with thesis papers. Knowing all ins and outs of how to write A-grade papers, we're willing to share this knowledge with
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JCI - Organotypic specificity of key RET adaptor-docking ...
This work was supported by an NIH George M. O’Brien Center for Kidney Disease Research grant (P30-DK079333) to Washington University, Children Discovery Institute grant MDII2009177 (to S. Jain), and NIH grants HD047396, DK081644 and DK082531 (to S. Jain), AG013730 (to J. Milbrandt), and DK57038, DK6459201 (to R.O. Heuckeroth).
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Issues in Language Studies | ILS (UNIMAS)
Issues in Language Studies or ILS (e-ISSN 2180-2726) is an open-access journal of the Faculty of Language and Communication, Universiti Malaysia Sarawak. The journal publishes articles on teaching, learning and the study of languages covering areas of linguistics, applied linguistics, language education, technology-mediated language learning, and other related areas.
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Judge Victoria A. Roberts - United States District Court
Judge Roberts also mediated collective bargaining issues in 2015 on behalf of the Detroit Water and Sewerage Department as the City of Detroit continued to bring closure to bankruptcy related issues. She is the recipient of numerous awards, including the two highest conferred by the State Bar of Michigan: The Roberts P. Hudson Award and the ...
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Why Does the Sun Make Some People Sneeze? - FOCUS - A ...
“The number of induced sneezes seems to be genetically mediated and can be predicted within a family,” said Benjamin S. Bleier, MD, FACS, a sinus surgeon at Mass. Eye and Ear. Photo sneeze reflex, or “sun sneezing,” is thought to …
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The Rotting Internet Is a Collective Hallucination - The ...
Just as the internet could have been structured as a big CompuServe, centrally mediated, but wasn’t, the web could have had any number of features to better assure permanence and sourcing.
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Antibacterial-Resistant Pseudomonas aeruginosa: Clinical ...
There are currently five characterized ribosomal methyltransferase enzymes (RmtA, RmtB, RmtC, RmtD, and ArmA) that have been found worldwide among clinical isolates of P. aeruginosa and Enterobacteriaceae (42, 60, 61, 265, 286, 287).
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Psychological Resilience and Positive Emotional ...
Laughter and humor. Laughter is good medicine. Laughter generates increases in positive emotion (Bachorowski & Owren, 2001) and produces self-reported improvements in immune system functioning (Mahoney, Burroughs, & Lippman, 2002).Importantly, the effect of laughter on the self-reports of immune system functioning is mediated by subjective experiences of …
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Emerging Issues in AAV-Mediated In Vivo Gene Therapy
Lessons Learned with AAV Vectors in the Clinic: Banking on the Experience with Liver Gene Transfer. The liver is a particularly attractive organ for the development of gene-based therapeutic approaches for a number of reasons including: (1) it is one of the body’s major biosynthetic organs; (2) studies in small- and large-animal models and in humans have …
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Frontiers | FcγR Binding and ADCC Activity of Human IgG ...
Antibody dependent cellular cytotoxicity (ADCC) is an Fc-dependent effector function of IgG important for anti-viral immunity and anti-tumor therapies. NK-cell mediated ADCC is mainly triggered by IgG-subclasses IgG1 and IgG3 through the IgG-Fc-receptor (FcγR) IIIa. Polymorphisms in the immunoglobulin gamma heavy chain gene likely form a layer of variation …
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Direct and Indirect Electron Transfer Routes of Chromium ...
Electron transfer mediated by iron minerals is considered as a critical redox step for the dynamics of pollutants in soil. Herein, we explored the reduction process of Cr(VI) with different crystalline ferric oxyhydroxides in the presence of pyrogenic carbon (biochar). Both low- and high-crystallinity ferric oxyhydroxides induced Cr(VI) immobilization mainly via the sorption …
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Type IV Hypersensitivity Reaction - StatPearls - NCBI ...
Type four hypersensitivity reaction is a cell-mediated reaction that can occur in response to contact with certain allergens resulting in what is called contact dermatitis or in response to some diagnostic procedures as in the tuberculin skin test. Certain allergens must be avoided to treat this condition.
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Frontiers | The Biology of Eosinophils and Their Role in ...
This review will describe the structure and function of the eosinophil. The roles of several relevant cell surface molecules and receptors will be discussed. We will also explore the systemic and local processes triggering eosinophil differentiation, maturation, and migration to the lungs in asthma, as well as the cytokine-mediated pathways that result in eosinophil activation and ...
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APC Gene - GeneCards | APC Protein | APC Antibody
APC (APC Regulator Of WNT Signaling Pathway) is a Protein Coding gene. Diseases associated with APC include Familial Adenomatous Polyposis 1 and Desmoid Disease, Hereditary.Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and Misspliced GSK3beta mutants stabilize beta-catenin.
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A review on plants extract mediated synthesis of silver ...
A large number of plants are reported to facilitate silver nanoparticles syntheses are mentioned and are discussed briefly in the presented review. The protocol for the nanoparticle syntheses involves: the collection of the part of plant of interest from the available sites was done and then it was washed thoroughly twice/thrice with tap water ...
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Advanced Materials: Vol 33, No 45
Tumor Therapy. In article number 2104779, Meng Zheng, Bingyang Shi, and co-workers develop a kind of polymeric siRNA micelle as an effective drug-delivery platform and potent RNAi nanomedicine for glioblastoma therapy.The siRNA micelles are capable of traversing the blood–brain barrier via transcytosis mediated by scavenger receptors, to subsequently …
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Modeling of drug-mediated CYP3A4 induction by using human ...
Briefly, for the definitive endoderm differentiation, human iPS cells were cultured for 4 days in L-Wnt-3A-expressing cell-conditioned RPMI1640 medium (Sigma) containing 100 ng/ml Activin A (R&D Systems), 1 × GlutaMAX, 0.2% fetal bovine serum (FBS), and 1 × B27 Supplement Minus Vitamin A (Life Technologies).
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Recent Advances in Exosome-Based Drug Delivery for Cancer ...
A number of accumulating studies have shown that exosome-mediated chemotherapeutic delivery can enhance anti-cancer effects [87,88,89,90,91]. Dox, one of the most effective anti-cancer drugs, is used for the treatment of …
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Home Page: Annals of Allergy, Asthma & Immunology
MOC-CME Reviews. What do allergists in practice need to know about non–IgE-mediated food allergies. Unlike immunoglobulin (Ig) E–mediated food allergy (FA), in which 1 pathophysiological mechanism explains 1 disease process, non-IgE FA encapsulates a number of disease states caused by different mechanisms but unified in their ability to cause …
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Hydroxylamine-mediated C–C amination via an aza-hock ...
Color labels are used to visualize the disconnection. a Hock rearrangement for phenol synthesis.b Our proposal for aniline synthesis.c This work with direct C–C amination via …
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Programmable editing of a target base in genomic ... - Nature
The number of positions ... We assessed BE2-mediated base editing efficiencies on the same ... A.C.K. and D.R.L. have filed a provisional patent application on …
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Allergic rhinitis - presentation
• Allergic rhinitis is defined as immunologic nasal response, primary mediated by immunoglobulin E (IgE). • Non-allergic rhinitis is defined as rhinitis symptoms in the absence of identifiable allergy, structure abnormality or sinus disease. 5.
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Recombinant Mouse M-CSF Protein 416-ML-010: R&D Systems
PI3K activation increases SDF-1 production and number of osteoclast precursors, and enhances SDF-1-mediated osteoclast precursor migration Authors: NS Adapala, S Root, J Lorenzo, H Aguila, A Sanjay Bone Rep, 2019;10(0):100203.
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TurboID-based proximity labeling reveals that UBR7 is a ...
Using the TurboID-based PL, a number of new regulators involved in the N NLR-mediated immune response were identified. In particular, we found that UBR7 interacts with N and functions as a ...
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Methylene-Tethered Arylsulfonation and Benzotriazolation ...
The Selectfluor-mediated approach toward the synthesis of methylene-tethered arylsulfonation and benzotriazolation of imidazopyridines has been described. The reaction involves imidazopyridine, aryl sulfinate, or benzotriazole and dimethyl sulfoxide (DMSO) in the presence of Selectfluor, where DMSO acts as a one-carbon synthon. The protocol has been …
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STEM CELL AGING. A mitochondrial UPR-mediated metabolic ...
Aging is characterized by physiological decline and increased susceptibility to pathologies and mortality. The rate of aging is controlled by evolutionarily conserved genetic pathways (1, 2).The general cause of aging is the chronic accumulation of cellular damage (2, 3).This conceptual framework raises fundamental questions about aging.
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A new type of ERGIC–ERES membrane contact mediated by ...
Membrane contact sites are defined as areas of close apposition (usually 10–30 nm in distance) formed between intracellular membrane compartments, in which membrane fusion is absent. 33,34,35 ...
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Cytoplasmic dynein-1 cargo diversity is mediated by the ...
Complexes composed of FTS, FHIP1B, and Hook1/Hook3 co-localize with Rab5-tagged early endosomes via a direct interaction between FHIP1B and GTP-bound Rab5. In contrast, complexes composed of FTS, FHIP2A and Hook2 colocalize with Rab1A-tagged ER-to-Golgi cargos and FHIP2A is involved in the motility of Rab1A tubules.
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CDC6 Gene - GeneCards | CDC6 Protein | CDC6 Antibody
CDC6 (Cell Division Cycle 6) is a Protein Coding gene. Diseases associated with CDC6 include Meier-Gorlin Syndrome 5 and Meier-Gorlin Syndrome 1.Among its related pathways are E2F mediated regulation of DNA replication and CDK-mediated phosphorylation and removal of Cdc6.Gene Ontology (GO) annotations related to this gene include nucleotide binding and …
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Innate or Adaptive Immunity? The Example of Natural Killer ...
Hapten-induced contact hypersensitivity (CHS) was previously thought to be mediated only by CD4 + T cells after priming mice with a chemical hapten. Unexpectedly, this NK cell–mediated CHS response in Rag-2–deficient mice could be detected for at least a month after chemical priming, and the response was hapten-specific.
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Acid- and Base-Mediated Hydrolysis of Dichloroacetamide ...
Safeners are used extensively in commercial herbicide formulations. Although safeners are regulated as inert ingredients, some of their transformation products have enhanced biological activity. Here, to fill gaps in our understanding of safener environmental fate, we determined rate constants and transformation products associated with the acid- and base-mediated …
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Medicines to Treat Immune-Mediated Diseases | Aldeyra ...
At Aldeyra, we’re a pioneer in the development of medicines to improve the lives of patients with immune-mediated diseases. Our pipeline of drug candidates is focused on inhibiting inflammatory cells linked to ocular and systemic conditions not adequately addressed by current treatments.
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14.1: Cell-Mediated Immunity - An Overview - Biology ...
Delayed hypersensitivity is generally used to refer to the harmful effects of cell-mediated immunity (tissue and transplant rejections, contact dermatitis, positive skin tests like the PPD test for tuberculosis, granuloma formation during tuberculosis and deep mycoses, and destruction of virus-infected cells).
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What is the international association for mediated divorce?
The International Association For Mediated Divorce is an international network of mediators dedicated to supporting and facilitating self-represented couples through the transition of divorce. These are mediators who provide Pro-se/Pre-suit divorce mediation and document preparation services.