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HLA-DQ2: The Primary Celiac Disease Gene - Verywell Health
HLA-DQ2 is one of two main celiac disease genes, and happens to be the most common gene implicated in celiac disease (HLA-DQ8 is the other so-called "celiac gene"). youngvet / Getty Images Most doctors believe you need at least one copy of either HLA-DQ2 or HLA-DQ8 to develop celiac disease.
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Coeliac Disease Diagnosis
Over 99% of people affected by coeliac disease have the HLA DQ2, HLA DQ8, or parts of these genes. Therefore, a negative test for these genes effectively rules out coeliac disease. The gene test on its own cannot diagnose coeliac disease – only 1 in 40 people who have HLA DQ2 or HLA DQ8 will develop coeliac disease.
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